ABSTRACT
Objective:To learn about the iodine nutritional status and the trend of iodine deficiency disorders in key populations in Changchun City, so as to provide basis for timely adoption of targeted prevention measures and scientific adjustment of intervention strategies.Methods:From 2018 to 2020, 10 counties (cities, districts) under the jurisdiction of Changchun City were divided into 5 sampling areas according to the directions of east, west, south, north and middle. One township (street) was randomly selected from each area, and 20 pregnant women and 40 non-boarding students aged 8 to 10 (half male and half female) of one primary school were selected from each township (street). Household salt samples and a random urine sample of pregnant women and children were collected for detection of salt iodine and urinary iodine; thyroid volume was checked in children aged 8 to 10.Results:From 2018 to 2020, the median range of edible salt iodine in children's home in Changchun City was 23.7 - 23.9 mg/kg, and the consumption rate of qualified iodized salt was 96.6%, 94.7% and 96.5%, respectively. The median range of edible salt iodine in pregnants' home was 23.7 - 25.3 mg/kg, and the consumption rate of qualified iodized salt was 97.6%, 95.9% and 96.1%, respectively. From 2018 to 2020, the median urinary iodine of children in Changchun City was 170.1, 192.7 and 175.2 μg/L, respectively, and the iodine nutritional status were all the appropriate level. The areas with the appropriate level of iodine each year accounted for 90% (9/10), 70% (7/10) and 80% (8/10), respectively, and the rest were exceeding the iodine appropriate areas. The median urinary iodine of pregnant women was 151.6, 163.1 and 161.0 μg/L, respectively, and the iodine nutritional status were all the appropriate level. The areas with the appropriate level of iodine each year accounted for 50% (5/10), 60% (6/10) and 60% (6/10), respectively, and the rest were all iodine deficient areas. A total of 2 000 children aged 8 to 10 were examined for thyroid volume, 3 cases of goiter were detected, and the goiter rate was 0.15%.Conclusion:From 2018 to 2020, the consumption rate of qualified iodized salt, urinary iodine level and goiter rate of children of key populations in Changchun City have reached the elimination standard of iodine deficiency disorders, but there is a risk of iodine deficiency in pregnant women in some areas.
ABSTRACT
Objective:To observe the clinical effects and safety of mifepristone combined with ethaeridine in inducing labor at sec-ond trimester of pregnant women with scarred uterus. Methods:Totally 84 cases were randomly divided into the control group and the study group with 42 ones in each. The control group received intrauterine injection of ethaeridine for inducing labor, and the study group received mifepristone additionally for inducing labor. The time intervals from administration to uterine contraction and from induc-tion to delivery, auxiliary medication rate, fetal weight, volume of postpartum hemorrhage, successful rate of induction, adverse events of induction and adverse drug reactions were compared. Results:Compared with those in the control group, the time intervals from ad-ministration to uterine contraction and from induction to delivery were shorter in the study group, and the clear uterine rate and total ad-verse event rate of induction were lower in the study group(P<0. 05). Conclusion: Mifepristone combined with ethaeridine is safer and more effective than ethaeridine alone, which is an appropriate alternative for inducing labor at second trimester of pregnant women with scarred uterus.